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澶ч氬僵绁ㄥ紑鎴峰彂鐜版鐗┾滄姉鐥呭皬浣撯

鏂囩珷鏉ユ簮锛閬椾紶涓庡彂鑲茬敓鐗╁鐮旂┒鎵   鍙戝竷鏃堕棿锛2019-04-05  銆愬瓧鍙凤細     銆  

[video:20190405妞嶇墿鍏嶇柅鑾风獊鐮 鍙戠幇鎶楃梾灏忎綋]

銆銆妞嶇墿鍏锋湁澶嶆潅銆佺簿缁嗚皟鎺х殑鍏嶇柅绯荤粺锛岀敤浜庤瘑鍒梾鍘熷井鐢熺墿銆佹縺娲婚槻鍗弽搴旓紝浠庤屼繚鎶よ嚜宸卞厤鍙椾镜瀹炽傛鐗╃粏鑳炲唴鏁扮洰浼楀鐨勬姉鐥呰泲鐧斤紝鏄洃鎺х梾铏镜瀹崇殑鍝ㄥ叺锛屼篃鏄姩鍛樻鐗╅槻鍗郴缁熺殑鎸囨尌瀹樸傛姉鐥呰泲鐧借鍙戠幇鑷充粖宸叉湁浜屽崄澶氬勾锛屼絾浜轰滑浠嶇劧涓嶆竻妤氬畠浠殑宸ヤ綔鍘熺悊銆傛竻鍗庡ぇ瀛︽煷缁ф澃鍥㈤槦銆佸ぇ閫氬僵绁峰畼缃慱澶ч氬僵绁锋渶鏂扮綉鍧 welcome銆愭敞鍐岄佺ぜ18k閲戙戦仐浼犱笌鍙戣偛鐢熺墿瀛︾爺绌舵墍鍛ㄤ凯姘戝洟闃熷拰娓呭崕澶у鐜嬪畯浼熷洟闃熸渶杩戠殑鑱斿悎鐮旂┒锛屽湪妞嶇墿鍏嶇柅鐮旂┒棰嗗煙鍙栧緱閲嶈绐佺牬銆傚悎浣滃洟闃熷彂鐜扮敱鎶楃梾铔嬬櫧缁勬垚鐨勬姉鐥呭皬浣撳苟瑙f瀽鍏剁數闀滅粨鏋勶紝浠庤屾彮绀轰簡鎶楃梾铔嬬櫧绠℃帶鍜屾縺娲荤殑鏍稿績鍒嗗瓙鏈哄埗锛屼负鏇村ソ鍒╃敤鎶楃梾铔嬬櫧鎻愪緵浜嗘柊鐨勫彲鑳姐鐩稿叧鎴愭灉浠ヤ袱绡囬暱鏂(Research Article)褰㈠紡锛屼簬45鏃ュ彂琛ㄥ湪鍥介檯瀛︽湳鏈熷垔銆婄瀛︺嬶紙Science锛Wang et al., 2019a, b)Science鏉傚織鍚屾湡鍙戣〃浜鍥介檯妞嶇墿鎶楃梾鐮旂┒鏉冨▉澶ч氬僵绁ㄥ紑鎴Jeffery DanglJonathan Jones鎾板啓鐨勯涓High five: a pentangular plant inflammasome 鐨勪笓鏂囪瘎杩帮紝楂樺害璇勪环杩欎竴鎴愭灉銆

銆銆鎶楃梾铔嬬櫧鐞嗚鐮旂┒鐨勪竴涓法澶х摱棰堝湪浜庣己涔忚泲鐧借川缁撴瀯銆傝繖姝f槸鏌寸户鏉板洟闃2004骞翠互鏉ョ殑涓绘敾鏂瑰悜銆傛姉鐥呰泲鐧芥瀯鎴愬鏉傘佸垎瀛愰噺澶с佹瀯璞″鍙橈紝瀵硅В鏋愬叾缁撴瀯甯︽潵浜嗘瀬澶у洶闅俱傝嚜浠25骞村墠鍥介檯涓婇娆¢壌瀹氬埌鎶楃梾铔嬬櫧浠ユ潵锛屽涓浗闄呴《灏栧疄楠屽鍧囨湭鑳界函鍖栧嚭鍙緵缁撴瀯鍒嗘瀽鐨勫叏闀挎姉鐥呰泲鐧借川銆傛煷缁ф澃鍥㈤槦杩戝勾鍦ㄥ姩鐗╃値鐥囧皬浣撶粨鏋勭爺绌朵腑鍙栧緱浜嗙獊鐮 (Hu et al., 2015; Yang et al., 2017)銆傜敱浜庣値鐥囧皬浣撶殑铔嬬櫧璐ㄤ笌妞嶇墿鎶楃梾铔嬬櫧鍏锋湁璇稿鐩镐技鎬э紝杩欎簺鐮旂┒涓鸿В鏋愭鐗╂姉鐥呰泲鐧界粨鏋勭Н绱簡瀹濊吹缁忛獙銆

銆銆鍛ㄤ凯姘戝洟闃熷拰鏌寸户鏉板洟闃熼氳繃鍚堜綔锛屾棭鍦2007-2008骞存彁鍑轰簡妞嶇墿涓庣梾鍘熺粏鑿岄棿鏀婚槻鐨勨滆楗垫ā鍨嬧濆苟鎻愪緵浜嗗垵姝ヨ瘉鎹(Xing et al., 2007, Xiang et al., 2008; Zhou and Chai, 2008)銆傚懆淇皯鍥㈤槦閫氳繃瀵圭梾鍘熻弻鍏嶇柅閫冮稿垎瀛愭満鍒跺拰妞嶇墿鍏嶇柅绯荤粺鍏抽敭缁勫垎鐨勮В鏋愶紝鍙戠幇浜嗗涓敮鎸佲滆楗垫ā鍨嬧濈殑鍒嗗瓙璇佹嵁 (Zhang et al., 2010; Feng et al., 2012; Wang et al., 2015) 骞跺湪2012骞村拰2015骞寸殑涓ら」宸ヤ綔涓紝鍙戠幇浜嗙梾鍘熺粏鑿屽拰妞嶇墿涔嬮棿浠や汉鎯婂徆鐨勬敾闃茬瓥鐣ャ傜梾鍘熺粏鑿岀殑涓涓嚧鐥呰泲鐧AvrAC绮惧噯鐮村潖妞嶇墿鍏嶇柅绯荤粺涓殑鍏抽敭缁勫垎锛屽府鍔╃粏鑿屼镜鏌撴鐗╁瘎涓伙紱鑰屾鐗╁垯鍒╃敤鐗规畩鐨勨滆楗碘濊泲鐧斤紝鎰熺煡AvrAC鐨勬椿鍔ㄥ苟灏嗕俊鎭紶閫掔粰妞嶇墿鎶楃梾铔嬬櫧ZAR1锛岃繀閫熸縺娲诲厤鐤弽搴旓紝娓呴櫎缁嗚弻銆備袱涓洟闃熷骞寸殑鍚堜綔銆佺粡杩囬暱鏈熺Н绱舰鎴愮殑鐞嗚鍜屽疄楠屼綋绯伙紝涓哄悗鏈熻繘涓姝ュ悎浣滃瀹氫簡鍧氬疄鍩虹銆傜帇瀹忎紵鍥㈤槦闀挎湡鑷村姏浜庡喎鍐荤數闀滄柟娉曞鐨勭爺绌躲佹彁楂樺拰鏀瑰杽锛屽铔嬬櫧璐ㄧ殑楂樺垎杈ㄧ巼鍐峰喕鐢甸暅閲嶆瀯涓鐩存槸璇ュ洟闃熺殑鐮旂┒鐒︾偣鍜岀壒闀匡紝杩欎负瑙f瀽鎶楃梾铔嬬櫧缁撴瀯瑙f瀽鎻愪緵浜嗗己鏈夊姏鐨勬妧鏈敮鎾戙

銆銆鍦ㄤ笂杩扮爺绌剁殑鍩虹涓婏紝涓変釜鍥㈤槦杩涗竴姝ュ悎浣滐紝浠AvrACZAR1涓轰綋绯荤爺绌舵鐗╂姉鐥呰泲鐧界粨鏋勩傜粡杩囧骞村崗浣滄敾鍏筹紝鎴愬姛鍦扮粍瑁呬簡鍖呭惈婵娲ZAR1鐨勫鍚堢墿 (鎶楃梾灏忎綋锛resistosome)銆傜粨鏋勭爺绌跺彂鐜帮紝ZAR1AvrAC婵娲诲悗锛岀粍瑁呮垚鍚笁涓簹鍩哄叡15涓泲鐧界殑鐜姸浜旇仛浣撹泲鐧芥満鍣紝褰㈡垚鎶楃梾灏忎綋 (1)銆傞氳繃瀵归潤鎭佸鍚堢墿鐨勭粨鏋勫拰鍔熻兘瑙f瀽锛岄槓鏄庝簡鎶楃梾铔嬬櫧鐢遍潤鎭姸鎬侊紝缁忚繃涓棿鐘舵侊紝鏈缁堝舰鎴愭姉鐥呭皬浣撶殑鐢熷寲杩囩▼銆傚悎浣滃洟闃熺揣瀵嗙粨鍚堢粨鏋勩佺敓鍖栧拰鍔熻兘鐮旂┒锛屾彮绀轰簡鎶楃梾灏忎綋宸ヤ綔鏈哄埗銆傛瘮濡傦紝鎶楃梾灏忎綋褰㈡垚鍚庣洿鎺ュ湪缁嗚優璐ㄨ啘涓婂彂鍑鸿嚜鏉鎸囦护锛屽緢鍙兘鏄鐗╃粏鑳炴浜″拰鍏嶇柅鎵ц鑰呫傝椤瑰伐浣滃~琛ヤ簡浜轰滑25骞存潵瀵规姉鐥呰泲鐧借鐭ョ殑绌虹櫧锛屼负鐮旂┒鍏跺畠鎶楃梾铔嬬櫧鎻愪緵浜嗚寖鏈傜爺绌惰繕鍙戠幇锛妞嶇墿鎶楃梾灏忎綋鐨勭粍瑁呮柟寮忋佺粨鏋勪笌鍔熻兘锛屼笌鍔ㄧ墿鍏嶇柅涓殑鐐庣棁灏忎綋鎯婁汉鍦扮浉浼硷紝灞曠幇浜嗗湪涓嶅悓鐢熷懡褰㈠紡涓紝杩涘寲瀵瑰厤鐤舰鎴愮殑鍔涢噺銆

銆銆Science鏉傚織鍚屾湡涓撴枃璇勮堪涓紝鍥介檯妞嶇墿鎶楃梾鐮旂┒鏉冨▉澶ч氬僵绁ㄥ紑鎴Jeffery DanglJonathan Jones瀵硅繖涓鎴愭灉缁欎簣楂樺害璇勪环锛氣滈涓姉鐥呭皬浣撶殑鍙戠幇锛屼负妞嶇墿濡備綍鎺у埗缁嗚優姝讳骸鍜屽厤鐤彁渚涗簡绾跨储鈥濄傘妞嶇墿瀛︽姤銆嬪悓鏃跺彂琛ㄥ浗闄呰憲鍚嶆鐗╂姉鐥呬笓瀹Xin Li锛堟潕鏄曪級绛変汉棰樹负銆寮鍚槻寰′箣闂細妞嶇墿鎶楃梾灏忎綋銆嬬殑涓撴枃璇勮堪锛岃涓鸿椤规垚鏋瀹屾垚浜嗘鐗NLR铔嬬櫧澶嶅悎鐗╃殑缁勮銆佺粨鏋勫拰鍔熻兘鍒嗘瀽锛屾彮绀轰簡NLR浣滅敤鐨勫叧閿垎瀛愭満鍒讹紝鏄鐗╁厤鐤爺绌剁殑閲岀▼纰戜簨浠

銆銆鍚勭鍐滀綔鐗╃梾铏锛屼弗閲嶅▉鑳佸啘涓氱敓浜с備负浜嗗噺灏戞崯澶憋紝鍐滀笟鐢熶骇涓笉寰椾笉澶ч噺鏂界敤鍖栧鍐滆嵂锛屼絾杩欏張瀵圭幆澧冦佷汉绫诲仴搴峰拰鍐滀笟鍙寔缁彂灞曞甫鏉ヤ簡鎸戞垬銆傚湪淇濇姢浣滅墿鐨勫悓鏃讹紝鍑忓皯鍖栧鍐滆嵂鐨勬柦鐢紝鎴愪负鎽嗗湪鍐滀笟鐢熶骇鑰呭拰澶ч氬僵绁ㄥ紑鎴烽潰鍓嶇殑涓閬撻毦棰樸傝В鍐宠繖涓闂鐨勫叧閿紝灏卞瓨鍦ㄤ簬妞嶇墿缁嗚優涓妞嶇墿缁嗚優鍐呮暟鐩紬澶氱殑鎶楃梾铔嬬櫧銆傝繖浜涜泲鐧藉彂鐜扮梾鑿屽悗锛岃繀閫熷惎鍔ㄦ鐗╅槻鍗弽搴旓紝鏉姝荤梾鑿岋紝浠庤屼繚鎶ゆ鐗╁厤鍙椾镜瀹炽傚埄鐢ㄦ姉鐥呰泲鐧斤紝鍙戝睍鏂扮殑鐥呰櫕瀹抽槻鎺ф墜娈碉紝鏈夋湜澶уぇ鍑忓皯鍖栧鍐滆嵂鐨勬柦鐢ㄣ鎶楃梾铔嬬櫧楂樺垎杈ㄥ害缁撴瀯鍜屼綔鐢ㄦ満鍒剁殑瑙f瀽锛屽皢涓鸿璁℃姉骞胯氨銆佹寔涔呯殑鏂板瀷鎶楃梾铔嬬櫧锛屽彂灞曠豢鑹插啘涓氬瀹氭牳蹇冪悊璁哄熀纭

銆銆娓呭崕澶у鍗氬+鍚庛閬椾紶鍙戣偛鎵妞嶇墿鍩哄洜缁勫鍥藉閲嶇偣瀹為獙瀹よ闂爺绌朵汉鍛樼帇缁х旱銆佹竻鍗庡ぇ瀛﹀崥澹悗鐜嬪涓閬椾紶鍙戣偛鎵妞嶇墿鍩哄洜缁勫鍥藉閲嶇偣瀹為獙瀹ゅ崥澹敓鑳℃濞熶负鍏朵腑涓绡囪鏂囩殑鍏卞悓绗竴浣滆(Wang et al., 2019a)锛涚帇缁х旱銆佽儭姊呭鍜岀帇瀹朵负鍙︿竴绡囪鏂囩殑鍏卞悓绗竴浣滆(Wang et al., 2019b)銆傛煷缁ф澃銆佸懆淇皯涓庣帇瀹忎紵涓轰袱绡囪鏂囩殑鍏卞悓閫氳浣滆呫傝椤圭爺绌跺緱鍒板ぇ閫氬僵绁ㄥ畼缃B绫诲厛瀵间笓椤浣滅墿鐥呰櫕瀹崇殑瀵煎悜鎬ч槻鎺э紞鐢熺墿闂翠俊鎭祦涓庤涓烘搷绾鍜屽浗瀹惰嚜鐒跺熀閲戝垱鏂扮兢浣撻」鐩滄鐗╁搷搴旂敓鐗╄儊杩殑鏈虹悊鈥濈瓑鐨勬敮鎸併

銆銆璁烘枃淇℃伅锛

銆銆Wang J#, Wang J#, Hu M#, Qi J, Wu S, Wang G, Han Z, Qi Y, Gao N, Wang HW*, Zhou JM*, Chai J* (2019a). Ligand-triggered allosteric ADP release primes a plant NLR complex. Science, vol: pages

銆銆Wang J#, Hu M#, Wang J#, Qi J, Han Z, Wang G, Qi Y, Wang HW*, Zhou JM*, Chai J* (2019b). Reconstitution and structure of a plant NLR resistosome conferring immunity. Science, vol: pages

 

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